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Faculty

Department of Anesthesiology

Martin Kaczocha, Role of fatty acid binding proteins in pain, inflammation, and related pathophysiologies: Endocannabinoid pharmacology and development of novel therapeutics.

Department of Biochemistry and Cell Biology

Michael Airola, Structural biology of lipid modifying enzymes

Ivet Bahar,Molecular systems biology, modeling and simulations of structural dynamics and interactions, design of modulators of function, applications to complex diseases

Nurit Ballas, The cellular and molecular mechanisms underlying the neurodevelopmental disorder Rett syndrome

Paul M. Bingham, Genetic control of development and gene expression in animals

Lina Carlini, Intracellular transport, organelle inheritance and dynamics

Vitaly Citovsky, Nuclear targeting and intercellular communication in plants

Neta Dean, Glycosylation; fungal pathogenesis

Ken Dill, Computer modeling of protein molecules and theory and principles of the machine mechanisms and evolution of cells

J. Peter Gergen, Gene expression and development in Drosophila

Steven Glynn, Structure and mechanism of protein-unfolding machines in mitochondria

Kathryn Gunn, Spatiotemporal regulation of metabolic enzymes

Bernadette C. Holdener, Genetic regulation of early mammalian development

Chi-Kuo Hu , Assistant Professor, biology of dormancy during development and aging, with the African killifish as the main research organism.

Wali Karzai, Biochemical, Structural, and Mechanistic Explorations of Protein and RNA Homeostasis.

Erwin London, Membrane protein structure/translocation/folding

Benjamin Lin, Cell dynamics and motility

Ed Luk, Chromosome biology and genome regulation

Benjamin Martin, Stem cell maintenance and differentiation, Developmental mechanisms of cancer pathogenesis

Aaron Neiman, Vesicle trafficking and membrane/cytoskeletal interactions

Jonathan Nelson, Repetitive DNA and transposable element regulation and its impact on maintaining genome stability

Dada Pisconti, Muscle stem cells; muscle development, regeneration and aging; muscular dystrophy; extracellular matrix; biology of proteoglycans.

Stuti Sharma, Mechanisms of membrane transporters using cryo-electron microscopy and biochemical tools

Gerald H. Thomsen, Growth factors /signal transduction in early vertebrate development

Department of Chemistry

Elizabeth Boon, Nitric oxide regulation of quorum sensing and biofilm formation in bacteria

Scott Laughlin, Chemical and biological strategies for deciphering neural circuitry

Carlos Simmerling, Development of tools for efficient and simulation of chemical systems and using them to study the structure and dynamics of molecules involved in biological processes.

Peter Tonge, Spectroscopic insights into enzyme mechanisms and structure 

Department of Medicine

Agnieszka Bialkowska, Acute and chronic pancreatitis, pancreatic cancer development, animal models, pancreatic stromal and immune cell interactions, single-cell and bulk NGS

Wen-Tien Chen, Proteases / integrins in cancer invasion, metastasis, angiogenesis

Christopher Clarke, Oncogenic reprogramming of sphingolipid metabolism and role in tumorigenesis

Berhane Ghebrehiwet, Biochemistry; function of the complement system

Yusuf Hannun, Bioactive lipids in cancer pathogenesis and therapeutics

Weiqin Lu, The major goal of my research is to unravel the role of inflammation and obesity in promoting oncogenic KRAS-mediated pancreatic tumorigenesis

Cungui Mao, Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy

Vincent Yang, Biology and pathobiology of intestinal epithelial stem cells and colorectal cancer.

Huichun Zhan, Stem cell biology in normal and neoplastic hematopoiesi

Department of Molecular Genetics & Microbiology

Jorge Benach, Pathogenesis of spirochetal infections and their host responses

Partha Biswas, Infection, Autoimmunity, Kidney, Immunology

Nicolas Carpino, Positive and Negative Regulation of T cell Receptor Signaling

Priyadharshini Devarajan, Enhancing Lung and Nasal Immune Defense Against Respiratory Viruses, Harnessing T Cell Memory for Enhanced Protection, Bolstering Aged Immune Responses to Combat Infections

Bruce Futcher, Cell cycle, cyclins, and yeast genetics

Patrick Hearing, Adenovirus regulation of cellular proliferation and gene expression; adenovirus vectors for human gene therapy

Hwan Kim, Rickettsial pathogenesis and vaccine assembly for tick-borne rickettsioses

James Konopka, Signal transduction, morphogenesis and genetics of pathogenic fungi

Pawan Kumar, Immunology, gut microbiota-immune cells interaction. Intestinal and autoimmune inflammation

Erich R. Mackow, Viral Pathogenesis, Regulation of Innate Immunity, Hantavirus, Dengue Virus and Rotavirus Regulation of Cell Signaling Responses, miRNAs and Endothelial cell functions.

Nancy Reich, Cytokine and Innate Immune Responses

Brian Sheridan, Mucosal Immunology, T cell memory, Vaccine design, Host-pathogen interactions

David Thanassi, Secretion of virulence factors by bacterial pathogens; pilus biogenesis by uropathogenic Escherichia coli

Adrianus. W.M. van der Velden, Infectious Diseases Immunology; Host Interactions with Bacterial Pathogens; Bacterial Immune Subversion

Department of Neurobiology and Behavior

Maurice Kernan, Molecular basis of mechanical senses

David McKinnonMolecular physiology of sympathetic neurons and cardiac muscle

Markus Riessland, We use state-of-the-art molecular tools to study cell type-specific pathways that underlie selective vulnerability and cellular senescence in brain-aging, age-related neurodegeneration and Parkinson’s disease.

Roger SherGenetic, molecular, and cellular mechanisms in Neurodegeneration

Prerana ShresthaDeveloping tools to manipulate protein synthesis, Translation control of long-term memories, and Stress-induced emotional dysregulation in anxiety disorders

Howard SirotkinGenetic and molecular analysis of early vertebrate development

Lonnie Wollmuth, Molecular mechanisms of synaptic transmission

Department of Oral Biology and Pathology

Soosan GhazizadehEpithelial stem cell biology; Skin bioengineering and gene therapy.

Department of Pathology

Jiang Chen, Skin and hair follicle development, maintenance and malignancy

Fei ChenMetabolic and epigenetic reprogramming of chemical carcinogenesis.

Jun ChungAnti-cancer drug discovery targeting tumor invasion and metastasis

Mehdi DamaghiThe role of tumor microenvironment in evolution of metabolic phenotypes in breast and ovarian cancer: from single cells to whole tumor analysis

Jingfang JuPost-transcriptional control of non-coding RNAs and RNA binding proteins in cancer

Richard R. Kew, Leukocyte chemotaxis/inflammation

Yupo Ma, Stem cell reprogramming and therapy, genome engineering, blood and marrow transplantation

Luis MartinezOncogenes and tumor suppressor genes, oncogenic functions of mutant p53

Ute MollTumor suppressor genes; mechanism of p53 inactivation

Scott PowersGenomic approaches to cancer research

Kenneth Shroyer, Cancer biomarkers as diagnostic adjuncts in cervical pathology and cytopathology; cervical cancer and HPV

Zhishan Wang, Environmental carcinogenesis, Cancer biology and Cancer therapy.

Chengfeng YangRNA dysfunction in carcinogenesis and resistance to cancer therapies 

Wei YangHarnessing the power of multi-level proteomics to understand and prevent cancer metastasis

Department of Pharmacological Sciences

Christopher BrownleeLeveraging microfluidics and optogenetics to elucidate molecular mechanisms of spindle orientation, ciliogenesis, polarity, actin cortex formation and axonogenesis

Holly ColognatoExtracellular matrix in the brain; roles during development and during neurodegeneration.

Bruce DempleDefining new repair pathways for oxidative DNA damage in the nucleus and the mitochondria of mammalian cells.

Michael A. FrohmanLipid signaling pathways in immune responses, Alzheimer's disease, cardiovascular disease, and cancer.

Miguel Garcia-Diaz, Genetic Toxicology/Mechanisms of mitochondrial gene expression

Arthur GrollmanMechanisms of chemical mutagenesis/carcinogenesis

Hyungjin Kim, Mechanisms of DNA damage response and repair in cancer susceptibility pathways

Jyoti Misra, Hippo signaling in Development and Cancer and Drug development

Joav PrivesCytoskeletal membrane interactions in muscle cells

Gilbert RahmeCancer epigenetics with a focus on brain tumors

Jessica C. Seeliger, Molecular mechanisms of bacterial cell membrane assembly

Markus Seeliger, Mechanism of Protein kinases and Ubiquitin Ligases in Cancer and Aging

Ken-Ichi TakemaruWnt Signaling in Development and Disease

Dongyan Tan, Structure and function of macromolecules involved in epigenetic regulation of gene expression

Styliani-Anna Tsirka, Neuronal-microglial interactions in the central nervous system

Ledong Wan, Role of RNA splicing in inflammation and cancer

Department of Physiology and Biophysics

Richard LinKinase signaling and cell proliferation

W. Todd Miller, Tyrosine phosphorylation and signal transduction

Eugene Serebryany, Protein folding, misfolding, aggregation, and conformation-phenotype relationships; disulfide bonds and protein chemistry; single-molecule protein sequencing; protein and peptide libraries

Ilan Spector, Neuronal differentiation and microfilaments

Thomas White, Molecular biology and physiology of gap junction channels

Brookhaven National Laboratory

Qun LiuStructural biology of membrane proteins and host-pathogen interactions, cellular structural biology.

F. William Studier, Phage T7 replication; large-scale nucleotide sequencing  

Cold Spring Harbor Laboratory

Christopher Hammell, Understanding how temporal precision in gene regulation contributes to normal development and how the modulation of protein translation impacts human cancer biology  

Leemor Joshua-Tor, Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography

Adrian KrainermRNA splicing; gene expression; RNA-protein interaction

Robert Martienssen, Plant genetics; transposons; development; gene regulation; DNA methylation

Alea MillsCancer; development; aging; senescence; epigenetics

David L. Spector, Spatial organization of gene expression

Bruce StillmanDNA replication and chromatin assembly in human and yeast cells

Nicholas K. Tonks, Characterization of protein tyrosine phosphatases

Lloyd Trotman, TheRapidCaP system to study metastatic prostate cancer genomes and their resistance to therapy in vivo

David A. Tuveson, Our laboratory investigates the fundamental mechanisms that contribute to the pathogenesis of pancreatic cancer, and applies this information to the development of new therapeutic and diagnostic approaches

Christopher Vakoc, Chromatin; epigenetics; acute myeloid leukemia; self-renewal; RNAi screening; mouse models of cancer

Linda Van Aelst, Signal transduction; Ras and Rac proteins, tumorigenesis

Michael H. Wigler, Growth control in yeast and mammalian cells